产品货号：
Z13111
中文名称：
CD146/MCAM抗体
英文名称：
Anti-CD146/MCAM Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-CD146/MCAM Antibody |
| 指标别名 | CD146;MCAM;MUC18 |
| 克隆性 | Polyclonal |
| 检验物种 | mouse,rat |
| 应用范围 | WB,IHC,IF,FCM,ELISA |
| 基因名称 | Mcam |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived mouse CD146/Mcam recombinant protein (Position:E27-E621). |
| 实际分子量 | 120KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt,-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | In humans,the CD146 protein is encoded by the MCAM gene.It is mapped to 9;9 A5.1.CD146 (cluster of differentiation 146) also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18,is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage.MCAM functions as a receptor for laminin alpha 4,a matrix molecule that is broadly expressed within the vascular wall.Accordingly,MCAM is highly expressed by cells that are components of the blood vessel wall,including vascular endothelial cells,smooth muscle cells and pericytes.Its function is still poorly understood,but evidence points to it being part of the endothelial junction associated with the actin cytoskeleton.A member of the Immunoglobulin superfamily,it consists of five Ig domains,a transmembrane domain,and a cytoplasmic region.It is expressed on chicken embryonic spleen and thymus,activated human T cells,endothelial progenitors such as angioblasts and mesenchymal stem cells,and strongly expressed on blood vessel endothelium and smooth muscle. |
| Uniprot ID | Q8R2Y2 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P) and ICC. |
| 基因名全称 | melanoma cell adhesion molecule |
| 蛋白名全称 | Cell surface glycoprotein MUC18 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry(Paraffin-embedded Section) 1:50～400 Immunofluorescence (IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells (ELISA)： 1:100～1000 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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